Association Between the C825T Polymorphism of the G Protein β3-Subunit Gene and Hypertension in Blacks
نویسندگان
چکیده
منابع مشابه
Association between polymorphism of the G-protein β3 subunit C825T and essential hypertension: an updated meta-analysis involving 36,802 subjects.
PURPOSE The G-protein β3-subunit gene C825T polymorphism (GNB3-C825T) has been reported to be associated with essential hypertension (EH), but results from previous studies are conflicting. The present study aimed at investigating the association between this polymorphism and risk of EH using a meta-analysis on the published studies. MATERIALS AND METHODS PubMed, Embase, CBM (China Biological...
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15 صفحه اولThe C825T Polymorphism of the G-Protein β3 Subunit Gene and Its Association with Hypertension and Stroke: An Updated Meta-Analysis
OBJECTIVE Several epidemiological studies have evaluated the association between the GNB3 C825T polymorphism and hypertension or stroke. The results of these studies were inconsistent; therefore, we performed a meta-analysis to clarify these discrepancies. METHODS We systematically searched the PubMed, Embase, Web of Science, CNKI, and CBM databases, and manually searched reference lists of r...
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BACKGROUND The guanine nucleotide-binding protein beta polypeptide 3 (GNB3) 825T allele encodes a product that enhances the activation of heterotrimeric G proteins, which is associated with the occurrence of the splice variant Gβ3 s that could play a role in vascular reactivity and hyperproliferation of smooth muscle cells, that makes such proteins attractive candidate gene products for suscept...
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ژورنال
عنوان ژورنال: Hypertension
سال: 1999
ISSN: 0194-911X,1524-4563
DOI: 10.1161/01.hyp.34.6.1193